Pstl and Rsal RFLPs in complete linkage disequilibrium at the CYP2E gene

PstI and RsaI RFLPs in complete linkage disequilibrium at the CYP2E gene.

Source/Description: A 1.5 kb Apal-Apal fragment, containing 5' upstream sequences of the human CYP2E gene (1). Polymorphism: Pstl detects a two allele polymorphism with bands at 6.1 kb (Cl) or 3.9 and 2.2 kb (C2). Rsal detects a two allele polymorphism with bands at 1.4 and 0.5 kb (Cl) or 1.9 kb (C2). These two polymorphisms are in complete linkage disequilibrium with each other. Other Comments...

The Pattern of Linkage Disequilibrium in Livestock Genome

Linkage disequilibrium (LD) is bases of genomic selection, genomic marker imputation, marker assisted selection (MAS), quantitative trait loci (QTL) mapping, parentage testing and whole genome association studies. The Particular alleles at closed loci have a tendency to be co-inherited. In linked loci this pattern leads to association between alleles in population which is known as LD. Two metr...

Linkage disequilibrium and molecular drive in the rDNA gene family.

DMLE+: Bayesian linkage disequilibrium gene mapping

SUMMARY The program DMLE+ allows Bayesian inference of the location of a gene carrying a mutation influencing a discrete trait (such as a disease) and/or other parameters of interest (such as mutation age) based on the observed linkage disequilibrium at multiple genetic markers. DMLE+ uses either individual marker genotypes, or haplotypes, integrates over uncertain population allele frequencies...

Homozygosity and linkage disequilibrium.

We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear ...